After three generations from the original crossing, the breed usually acquires a gentle domestic cat temperament; however, for the typical pet owner, a Bengal cat kept as a pet should be at least four generations (F4) removed from the leopard cat. The so-called foundation cats from the first three filial generations of breeding (F1–F3) are usually reserved for breeding purposes or the specialty pet home environment. Bengals are known for liking water, and require a large amount of attention to keep them happy. Bengals also enjoy playing, and have been recorded jumping over 4 feet from the ground.

A novel autosomal recessive disorder was described in Bengals in 2011, decades after the breed's development. This disease appears to be an early-onset primary photoreceptor disorder, leading to blindness within the first year of age, in cats that possess the anomaly.